Resources for the Future has a long tradition of pioneering research on health issues, including early work on schistosomiasis control, fertility, and a seminal 1970 study exploring the link between air pollution and mortality. Today RFF researchers are building on that tradition by employing creative approaches to a host of health-related policy challenges. These include responding to the growing threat of drug resistance in disease-causing pathogens, valuing disparate health outcomes, setting disease control priorities and health policy in developing countries, devising strategies to control and eliminate malaria, and enhancing food safety. By applying methods first developed in the environmental economics field to the analysis of health issues, RFF research is opening up new avenues for cross-disciplinary research and policy solutions.