Biography
Maciej Boni's research focuses on the public health consequences of the evolution of infectious diseases. He has studied antigenic drift in the influenza virus, a process which allows influenza to elude vaccine-induced immunity, and the evolution of antibiotic resistance in bacteria. His work analyzes the fundamental mechanisms that drive these processes so that policy can be formulated with some knowledge as to its effects on the evolution of the disease in question. In addition, Boni has contributed to the statistical theory required for identifying recombinant viruses and bacteria; these recombinant organisms are often implicated in resistance evolution and, in the case of influenza, potentially pandemic strains. His work has enabled the searching of large databases for potentially novel and dangerous disease strains.
Boni currently works with Ramanan Laxminarayan (RFF) and David L. Smith (U. Florida) on the economic and ecological challenges to developing effective malaria treatment strategies. He is a postdoctoral fellow at the Princeton Environmental Institute and has active collaborations with researchers at Penn State's Center for Infectious Disease Dynamics, the University of Chicago, Queen's University (Ontario), the University of Vigo (Spain), the Institute for Research and Development (France), and the University of Queensland (Australia).
Ph.D. in Biological Sciences, StanfordUniversity, 2006 M.S. in Computational Mathematics, StanfordUniversity, 2004 A.B. in Mathematics, PrincetonUniversity, 1999
Professional Experience
Postdoctoral fellow, Princeton Environmental Institute and Department of Ecology and Evolutionary Biology, PrincetonUniversity, 2007 - present
Postdoctoral scholar, StanfordGenomeTechnologyCenter, Stanford University School of Medicine, 2006 - 2007
Consultant, Scholastic Corporation and Tigris Consulting, 1999 - 2000, 2002
Journal Articles
Homologous recombination is very rare or absent in human influenza A virus Boni MF, Zhou Y, Taubenberger JK, Holmes EC Journal of Virology | May 2008 | Vol. 82, No. 10 | pp. 4807-4811
Vaccination and antigenic drift in influenza Boni MF Vaccine | forthcoming
An exact nonparametric method for inferring mosaic structure in sequence triplets Boni MF, Posada D, and Feldman MW Genetics | 2007 | Vol. 176 | pp.1035-1047
Epidemic dynamics and antigenic evolution in a single season of influenza A. Boni MF, Gog JR, Andreasen V, Feldman MW Proceedings of the Royal Society of London B | 2006 | Vol. 273 | pp.1307-1316
Species and functional diversity of native and human-dominated plant communities Mayfield MM, Boni MF, Daily GC, Ackerly D Ecology | 2005 | Vol. 86, No. 9 | pp.2365-2372
Evolution of antibiotic resistance by human and bacterial niche construction Boni MF, Feldman MW Evolution | 2005 | Vol. 59, No. 3 | pp. 477-491
Influenza drift and epidemic size: the race between generating and escaping immunity Boni MF, Gog JR, Andreasen V, Christiansen FB Theoretical Population Biology | 2004 | Vol. 65, No. 2 | pp.179-191
Books, Chapters, and Reports
Dynamics and control of antibiotic resistance in structured metapopulations Smith DL, Boni MF, Laxminarayan R Disease Evolution: Models, Concepts, and Data Analyses | Zhilan Feng, Ulf Dieckmann, Simon Levin | Providence, Rhode Island: American Mathematical Society | 2006
Discussion Papers and Working Papers
Controlling avian influenza in chickens Malani A, Boni MF, Wickelgren A, Laxminarayan R Harvard University Seminar in Law, Economics, and Organization Research, Item #8 | April 23, 2007
Selected Presentations
Searching for Recombination and Reassortment Among Influenza Viruses Maciej F. Boni Oxford Tropical Disease Network Meeting | MRC Laboratories | Banjul, The Gambia | February 20, 2008
Homologous Recombination is Absent or Very Rare Among Influenza Viruses Maciej F Boni, Yang Zhou, Edward C Holmes Feldmania: Population Genetics Meeting for Marc Feldman's 65th Birthday | Stanford California | November 17, 2007
Multi-drug population-wide treatment strategies against malaria Maciej F. Boni, Ramanan Laxminarayan, David L. Smith Gordon Research Conference, Special Session | Oxford, UK | September 13, 2007
Nonparametric methods for detecting recombination in sequence data Maciej F. Boni Health Research and Policy Workshop in Biostatistics | Stanford University School of Medicine | Stanford, CA | November 9, 2006 The University of Vigo, Vigo, Spain (Sep 22 2006).
Antigenic drift in influenza: models and data Maciej F. Boni Workshop on Pathogen Diversity and Disease Epidemiology | Instituto Gulbenkian de Ciência | Oeiras, Portugal | September 18, 2006 Institute for Research and Development, Montpellier, France (May 9 2007).
Antigenic drift in a single season of influenza Maciej F. Boni DIMACS Workshop on Epidemiology and Evolution of Influenza | Alan Perelson, Catherine Macken | Rutgers University, New Brunswick, NJ | January 26, 2006 Center for Infectious Disease Dynamics, Pennsylvania State University (Jan 24 2006).
DIMACS Workshop on Evolutionary Considerations in Vaccine Use (Jun 29 2005).
California Population and Evolutionary Genetics Meeting (Dec 11 2004).
A simple influenza model with annual dynamics and antigenic drift Maciej F. Boni DIMACS Working Group on the Ecology and Evolution of Influenza and Related Viruses | Rutgers University, New Brunswick, NJ | June 30, 2003 Aarhus University Bioinformatics Research Center (Jun 2003).
Awards
Samuel Karlin Prize for Ph.D. Thesis in Mathematical Biology, 2006 National Science Foundation Graduate Fellowship, 2001 - 2004 Stanford Graduate Fellowship, 2001 - 2004 Fulbright Scholarship to study Mathematical Biology in Denmark, 2000 - 2001
Professional Activities
Journal Referee:
Proceedings of the Royal Society of London B Journal of the Royal Society Interface Genetics PLoS Medicine PLoS One Theoretical Population Biology Infection, Genetics, and Evolution Mathematical Biosciences and Engineering
